Use Bisoprolol is indicated for use in adults for: - Arterial hypertension. - Coronary heart disease: stable angina. - Chronic heart failure (CHF). How to take Bisoprolol is taken orally, on an empty stomach in the morning, without chewing. The recommended initial dose is 5 mg once daily. If necessary, the dose can be increased to 10 mg once a day. The maximum daily dose is 20 mg. In patients with impaired renal function (creatinine clearance less than 20 ml/min) or severe impaired liver function, the maximum daily dose is 10 mg. Dose adjustment is usually not required in elderly patients. Contraindications - Hypersensitivity to bisoprolol or to any of the excipients. - Acute heart failure or chronic heart failure in a decompensated stage requiring intravenous inotropic therapy. - Cardiogenic shock. - AV block II and III degree (without a pacemaker). - Sick sinus syndrome. - Sinoatrial block. - Pronounced bradycardia (heart rate less than 60 beats per minute before starting therapy). - Pronounced arterial hypotension (systolic blood pressure less than 100 mmHg). - Severe forms of bronchial asthma and chronic obstructive pulmonary disease (COPD). - Late stages of peripheral circulatory disorders or Raynaud's syndrome. - Pheochromocytoma (without concomitant use of alpha-blockers). - Metabolic acidosis. - Age under 18 years (insufficient data on efficacy and safety). - Concomitant use of MAO inhibitors (except MAO-B).