Use Progynova is used for hormone replacement therapy (HRT) for symptoms of estrogen deficiency in postmenopausal women (not earlier than 6 months after the last menstruation in the case of natural menopause, or immediately after menopause as a result of surgical intervention, such as bilateral oophorectomy). It helps with symptoms such as hot flashes, increased sweating, sleep disturbances, depression, nervousness, irritability, headaches, dizziness, bladder hyperesthesia, degenerative changes in the skin and mucous membranes. Progynova is also used for the prevention of postmenopausal osteoporosis in women with a high risk of fractures, when other medicines for osteoporosis prevention are not tolerated or contraindicated. How to take Progynova dragees are taken whole, with a glass of water or milk, regardless of food intake. The daily dose is 1-2 mg. After finishing the dragees from one package, treatment with a new package should be started without interruption. Pregnancy must be ruled out before starting therapy with the drug. Contraindications Progynova is contraindicated during pregnancy and breastfeeding. Contraindications also include hypersensitivity to the components of the drug, severe liver dysfunction, Dubin-Johnson and Rotor syndromes, liver tumors and thromboembolic processes (including in anamnesis), breast cancer, existing or suspected tumors sensitive to sex steroid hormones, severe hypertriglyceridemia, as well as vaginal bleeding of unknown etiology.