Use: Doxycycline-Asteria is indicated for the treatment of various infections, including rickettsial infections (Rocky Mountain spotted fever, typhus group, Q fever, Coxiella endocarditis, and tick fevers), as well as other infections such as psittacosis, cholera, melioidosis, leptospirosis, infections caused by susceptible strains of Yersinia and Brucella (in combination with streptomycin), Clostridium, Francisella tularensis, and chloroquine-resistant malaria. The drug is also indicated for the prevention of typhus, traveler's diarrhea (caused by enterotoxigenic Escherichia coli), and leptospirosis. How to take: - Typhus prevention: 200 mg once. - Prevention of traveler's diarrhea in adults: 200 mg on the first day of travel (single dose or 100 mg every 12 hours), then 100 mg daily throughout the stay in the area. Data on the use of the drug for prevention for more than 21 days are not available. - Leptospirosis prevention: 200 mg weekly during the stay in the area and 200 mg at the end of the trip. Data on the use of the drug for prevention for more than 21 days are not available. Contraindications: Doxycycline-Asteria is contraindicated in cases of hypersensitivity to the active substance, any of the tetracyclines, or any of the excipients. The drug is contraindicated during pregnancy, as the risks associated with the use of tetracyclines during this period are primarily related to effects on tooth and bone development. It is also contraindicated in breastfeeding mothers, as tetracyclines are excreted in breast milk.