Use: Rosuvastatin (the active substance of Rovastat) is used for hypercholesterolemia (type IIa, including heterozygous familial hypercholesterolemia) or mixed hypercholesterolemia (type IIb) as an adjunct to diet when diet and other non-pharmacological treatments (e.g., exercise, weight reduction) are insufficient. It is also used for homozygous familial hypercholesterolemia as an adjunct to diet and other cholesterol-lowering therapy or in cases where such therapy is not suitable for the patient. How to take: The recommended starting dose is 10 mg once daily. If necessary, the dose may be increased to 20 mg after 4 weeks. An increase in dose to 40 mg is possible only in patients with severe hypercholesterolemia and a high risk of cardiovascular complications (especially in patients with familial hypercholesterolemia) with insufficient effectiveness at a dose of 20 mg and under medical supervision. Contraindications: The drug is contraindicated during pregnancy, breastfeeding, active liver disease (including persistent elevation of liver transaminases or any elevation of transaminases more than 3 times the upper limit of normal). It is also contraindicated in severe renal insufficiency (creatinine clearance less than 30 ml/min) and for use in children.