Sandostatin solution for injection 100mkg/1ml №5

Sandostatin is a synthetic octapeptide, a derivative of the natural hormone somatostatin, possessing similar but significantly more prolonged pharmacological effects. Release form: Solution for intravenous and subcutaneous administration, clear, colorless. 0.1 mg/ml, 1 ml in an ampoule. In a cardboard package of 5 ampoules. Composition: 1 ml of solution contains: - Active substance: octreotide (in the form of free peptide) 100 mcg (0.1 mg). - Excipients: lactic acid, mannitol, sodium bicarbonate, carbon dioxide, water for injection. Pharmacokinetics: Plasma protein binding is 65%. Total clearance is 160 ml/min. The half-life after subcutaneous injection is 100 min. After intravenous administration, the elimination process occurs in 2 phases, with half-lives of 10 min and 90 min, respectively. Use Sandostatin suppresses the secretion of growth hormone (GH), both pathologically elevated and induced by arginine, physical exercise, and insulin hypoglycemia. It also suppresses the secretion of various peptides and serotonin produced in the gastroenteropancreatic endocrine system, as well as the secretion of insulin, glucagon, and other hormones. How to take The dose is set individually, depending on the nature of the disease, treatment regimen, and the dosage form used. Octreotide in the conventional duration of action dosage form is administered subcutaneously and by intravenous drip.