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Use The Oral-B 3-Effect Maxi Clean medium toothbrush is designed for deep cleaning between teeth. It features Triple Fan bristles, engineered to penetrate deep between teeth, and a raised power tip specifically designed to effectively reach and clean back teeth. The brush also has colored indicator bristles that fade over time, signaling when it's time to replace the brush. - How to take It is recommended to brush teeth twice a day with fluoride toothpaste. The toothbrush should be replaced every three months. - Contraindications No explicit contraindications for the use of this toothbrush are stated.