Metformin-Denk coated tablets 500mg №100

Use Metformin is indicated for type 2 diabetes mellitus (non-insulin-dependent) in cases where diet therapy and physical activity are ineffective, especially in obese patients. In adults, it is used as monotherapy or in combination with other oral hypoglycemic agents or with insulin. In children aged 10 years and older, metformin is used as monotherapy or in combination with insulin. How to take - Adults: The usual starting dose is 500 mg twice daily or 850 mg once daily, taken with or immediately after food. The dose can be gradually increased to reduce gastrointestinal side effects, usually weekly, in 500 mg increments. The maximum daily dose for adults generally does not exceed 2550 mg, divided into 2-3 doses. - Children (10 years and older): The initial dose is 500 mg twice daily. The maximum daily dose for children usually does not exceed 2000 mg, divided into 2-3 doses. - Tablets should be swallowed whole, without chewing or crushing. Contraindications Metformin is contraindicated during pregnancy and breastfeeding. It is also contraindicated in severe liver and kidney dysfunction (creatinine clearance less than 30 ml/min). Metformin is not recommended for patients over 60 years of age due to an increased risk of lactic acidosis. The use of the drug is contraindicated in children and adolescents under 10 years of age.