Use: Quamatel is used in adults over 18 years of age for the treatment of the following conditions: duodenal and gastric ulcers without malignancy in the acute phase, prevention of recurrence; gastroesophageal reflux disease; other conditions accompanied by hypersecretion (e.g., Zollinger-Ellison syndrome); prevention of aspiration of gastric juice during general anesthesia (Mendelssohn's syndrome). How to take: - For gastric and duodenal ulcers in the acute phase, Quamatel is prescribed at a dose of 40 mg once daily before bedtime or 20 mg twice daily, in the morning and evening. The average course of treatment is 4-8 weeks. If necessary, the daily dose can be increased to 80-160 mg. - For the prevention of exacerbations of gastric and duodenal ulcers, Quamatel is prescribed at a dose of 20 mg once daily before bedtime. - For gastroesophageal reflux disease, the drug is taken at 20 mg twice daily (morning and evening) for 6-12 weeks. If gastroesophageal reflux disease is accompanied by esophagitis, the recommended dose of Quamatel is 20-40 mg/day for 12 weeks. Contraindications: In case of hepatic insufficiency or a history of liver cirrhosis with portosystemic encephalopathy, Quamatel should be used with caution and in lower doses. Since famotidine is excreted predominantly by the kidneys, the drug should be used with caution in renal insufficiency. When creatinine clearance decreases below 10 ml/min, a reduction in the daily dose of the drug is recommended. Quamatel is not recommended for use during pregnancy. Breastfeeding should be discontinued during the use of Quamatel. Storage: Store in a sun-protected room at a maximum permissible temperature of 25degreeC.