Use Rosulip Plus is indicated as an adjunct to diet in patients with primary hypercholesterolemia (including heterozygous familial hypercholesterolemia). Rosulip Plus is prescribed as replacement therapy for patients whose lipid profile has been adequately controlled by the concomitant use of individual preparations of rosuvastatin and ezetimibe at doses equivalent to the corresponding doses in a fixed combination. How to take Patients should be on an appropriate lipid-lowering diet (hypocholesterolemic diet). During treatment with Rosulip Plus, patients should continue this diet. The recommended daily dose is 1 capsule. Contraindications - Hypersensitivity to rosuvastatin, ezetimibe, or any of the components/excipients of the drug. - Active liver disease, including persistent elevation of serum transaminase activity and any increase in serum transaminase activity (> 3 times the upper limit of normal (ULN)). - Moderate to severe hepatic impairment (7-9 or more points on the Child-Pugh scale). - Concomitant use of cyclosporine. - In women: pregnancy, breastfeeding period, absence of reliable contraception methods in women of reproductive potential. - Severe renal impairment (CrCl < 30 ml/min). - Myopathy. - Predisposition to myotoxic complications. - Children and adolescents under 18 years of age. - Concomitant use of sofosbuvir/velpatasvir/voxilaprevir. Storage Store at a temperature not exceeding 30 degreeC, out of reach of children.