Use Bisoprolol is indicated for use in adults for: - Arterial hypertension. - Coronary heart disease (stable angina). - Chronic heart failure (CHF). How to take Bisoprolol is taken orally once a day with a small amount of water, regardless of food intake. Tablets should not be chewed or crushed into powder. In all cases, the regimen and dosage are selected by the doctor individually for each patient, in particular, taking into account the heart rate and therapeutic response. For arterial hypertension and coronary heart disease, the usual starting dose is 5 mg once a day. If necessary, the dose is increased to 10 mg once a day. The maximum daily dose for the treatment of arterial hypertension and angina is 20 mg once a day. It is possible to divide the daily dose into 2 administrations. Contraindications - Acute heart failure or chronic heart failure in the decompensation stage, requiring intravenous inotropic therapy. - Cardiogenic shock. - AV block of II or III degree (without pacemaker). - Sick sinus syndrome. - Sinoatrial block. - Severe bradycardia (heart rate less than 60 bpm before therapy). - Severe arterial hypotension (systolic blood pressure less than 100 mmHg). - Severe forms of bronchial asthma or chronic obstructive pulmonary disease (COPD). - Late stages of peripheral circulatory disorders or Raynaud's syndrome. - Pheochromocytoma (without concomitant use of alpha-blockers). - Metabolic acidosis. - Hypersensitivity to bisoprolol or any of the excipients. - Pregnancy. - Breastfeeding period. - Pediatric age. Storage Store at a temperature from 2 to 25 degreeC.