Fromilid Uno coated tablets 500mg №7

Use: Fromilid UNO is indicated for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to clarithromycin. These include infections of the upper respiratory tract and ENT organs (such as tonsillopharyngitis, acute otitis media, acute sinusitis), infections of the lower respiratory tract (acute bronchitis, exacerbation of chronic bronchitis, community-acquired bacterial and atypical pneumonia), odontogenic infections, skin and soft tissue infections, as well as mycobacterial infections (M. avium complex, M. kansasii, M. marinum, M. leprae, M. chelonae, M. fortuitum). - How to take: For tonsillitis and acute otitis media, adults and children over 18 years of age are recommended to take 1 tablet (500 mg) once a day with meals. For severe infections, the dose can be increased to 2 tablets (1000 mg) once a day with meals. The usual duration of treatment is from 5 days. - Contraindications: The drug is contraindicated in patients with a history of QT interval prolongation, ventricular arrhythmia, or torsades de pointes. Contraindications also include hypokalemia (due to the risk of QT interval prolongation), severe hepatic impairment concurrent with renal impairment, cholestatic jaundice/hepatitis in history developed with clarithromycin use, and porphyria. Fromilid UNO should not be used in the first trimester of pregnancy and during lactation (breastfeeding). Concomitant use of clarithromycin is contraindicated with: - astemizole - cisapride - pimozide - terfenadine - ergot alkaloids (e.g., ergotamine, dihydroergotamine) - oral midazolam - HMG-CoA reductase inhibitors (statins) that are extensively metabolized by CYP3A4 isoenzyme (lovastatin, simvastatin) - colchicine - ticagrelor or ranolazine. Hypersensitivity to clarithromycin and other macrolides is also a contraindication. - Storage: Store at a temperature from 5 degreeС to 25 degreeС.