Use - Regulation of the physiological rhythm of large bowel emptying in constipation in adults and children from 0 to 18 years. - Softening of stool for medical purposes, for example, in cases of hemorrhoids or conditions after surgery on the large intestine and in the anal area. - Treatment and prevention of hepatic coma or precoma (hepatic encephalopathy) in adults. - How to take The daily dose of lactulose can be taken once or divided into two parts using a measuring cup. The initial dose can be adjusted to a maintenance dose depending on the response to the drug. The therapeutic effect may appear 2-3 days after the start of administration. For constipation or stool softening: - Adults and adolescents: the initial daily dose is usually 15-45 ml, maintenance dose - 15-30 ml. - Children 7-14 years: initial daily dose 10-15 ml, maintenance dose - 10-15 ml. - Children 1-6 years: initial and maintenance daily dose 5-10 ml. - Children under 1 year: initial and maintenance daily dose up to 5 ml. - For accurate dosing in children under 7 years, it is recommended to use the drug in bottles. For hepatic encephalopathy (in adults): - The initial dose is 30-45 ml (2-3 sachets) 3-4 times a day. - The dose is then adjusted by the attending physician so that soft stools occur no more than 2-3 times a day. - In acute cases (precoma or coma), the drug can be administered as a retention enema (300 ml of the drug diluted in 700 ml of water). - Contraindications - Galactosemia. - Intestinal obstruction. - Perforation or risk of gastrointestinal tract perforation. - Hypersensitivity to any component of the drug. - Galactose or fructose intolerance, lactase deficiency, or glucose-galactose malabsorption.