Use Indomethacin is used for acute and chronic pain associated with inflammatory and degenerative diseases of the musculoskeletal system. These include: - rheumatoid arthritis, - juvenile chronic arthritis, - ankylosing spondylitis (Bechterew's disease), - gouty arthritis, - psoriatic arthritis, - Reiter's disease. The drug is also indicated for rheumatic soft tissue lesions, such as: - tendinitis, - bursitis, - tendobursitis, - tendovaginitis. It is used for discopathies, neuritis, plexitis, radiculoneuritis, as well as for pain relief and inflammation after injuries and surgical interventions. How to take Indomethacin is taken orally. The initial dose for adults is 25 mg 2-3 times a day. If the effect is insufficient, the dose can be increased to 50 mg 3 times a day. The maximum daily dose should not exceed 200 mg. For long-term use, the maximum daily dose should not exceed 75 mg. After achieving the therapeutic effect, treatment is continued for 4 weeks at the same or a reduced dose. Contraindications Indomethacin is contraindicated in cases of hypersensitivity to indomethacin or other components of the drug, as well as to NSAIDs. Contraindications include: - erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, - ''aspirin triad'' (combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses, and intolerance to acetylsalicylic acid and other NSAIDs), - hematopoietic disorders, - severe liver and/or kidney dysfunction. The drug is also contraindicated in severe forms of chronic heart failure, arterial hypertension, pancreatitis, in the III trimester of pregnancy, and during breastfeeding. It is not recommended for use in children under 14 years of age.