Use Creon 25000 is used in replacement therapy for exocrine pancreatic insufficiency in children and adults. This condition is often associated with the following diseases and conditions: cystic fibrosis, chronic pancreatitis, pancreatectomy, pancreatic cancer, duct obstruction (e.g., due to a tumor), Shwachman-Diamond syndrome, post-acute pancreatitis attack, and other gastrointestinal diseases. The drug is also indicated for conditions accompanied by digestive disorders, such as partial gastric resection (e.g., Billroth II), gastrectomy, gastrointestinal surgeries, Zollinger-Ellison syndrome, excessive bacterial growth in the small intestine, liver cirrhosis, cholestatic hepatitis, and in elderly individuals. How to take Creon 25000 capsules are taken orally. Doses are selected individually, depending on the severity of the disease and the diet composition. Capsules should be taken during or immediately after each meal or light snack. They must be swallowed whole, without breaking or chewing, with a sufficient amount of liquid. If swallowing the capsule whole is difficult (e.g., in small children or elderly patients), it can be carefully opened, and the minimicrospheres added to liquid food that does not require chewing, or taken with liquid. The mixture of minimicrospheres with food or liquid is not subject to storage and must be taken immediately after preparation. Contraindications Creon 25000 should not be taken in the early stages of acute pancreatitis. The drug is also contraindicated in cases of hypersensitivity to porcine pancreatin or to any other component of the drug.