Use Mirtazapine Canon is indicated for depressive states, including symptoms such as anhedonia (inability to experience pleasure and joy), psychomotor retardation, insomnia, early awakening, weight loss, loss of interest in life, suicidal thoughts, and mood lability. The drug is most effective in anxious depressions of various origins. How to take The effective oral dose for adults is 15-45 mg/day, primarily once a day before sleep. The dose should be gradually increased to 30-45 mg/day. The antidepressant effect develops gradually, usually within 2-3 weeks of starting treatment, but administration should continue for another 4-6 months. If no therapeutic effect is observed within 6-8 weeks of treatment, it should be discontinued. Mirtazapine withdrawal should be gradual. Contraindications Mirtazapine Canon is contraindicated during pregnancy and breastfeeding. Use with caution in patients with epilepsy and organic brain lesions, impaired liver and/or kidney function, acute cardiovascular diseases, arterial hypotension, urinary disorders due to benign prostatic hyperplasia, angle-closure glaucoma, and diabetes mellitus. Mirtazapine should also be prescribed with caution to elderly patients. The safety and effectiveness of mirtazapine in the pediatric population have not been established.