Use Ziglipe 145 mg tablets are indicated as an adjunct to diet and other non-pharmacological treatments (e.g., exercise, weight reduction) in the management of severe hypertriglyceridemia with or without low HDL cholesterol. It is also used in mixed hyperlipidemia when statins are contraindicated or poorly tolerated by the patient, as well as in mixed hyperlipidemia in patients with high cardiovascular risk as an adjunct to statins when triglycerides and HDL cholesterol are not adequately controlled. Ziglipe can be used in addition to other drugs (statins) in cases where blood fat levels are not controlled by statins alone. How to take The recommended dose is one tablet per day. Tablets can be taken with or without food, at any time of the day. Extended-release capsules can generally be taken regardless of food intake. They should be swallowed whole, without opening. Always follow the instructions in the package leaflet or the recommendations of your doctor/pharmacist. Contraindications Contraindications to the use of fenofibrate may vary depending on the specific dosage form and individual patient characteristics. It is important to always consult a doctor before starting the medication. General contraindications include hypersensitivity to fenofibrate or any of the excipients of the drug, including allergic reactions such as skin rash, itching, urticaria, swelling, or difficulty breathing. Severe liver dysfunction (including primary biliary cirrhosis) is also a contraindication. Do not take Ziglipe if you have an intolerance to certain types of sugars, which should be discussed with a doctor. Ziglipe is not recommended for use in individuals under 18 years of age.