Use Prestans is used in adults for the treatment of arterial hypertension and/or ischemic heart disease (IHD): stable exertional angina in patients who require therapy with amlodipine and perindopril. Contraindications - Hypersensitivity to the active substances, to other ACE inhibitors or other dihydropyridine derivatives, or to any of the excipients; - Angioedema (Quincke's edema) in anamnesis (including during treatment with other ACE inhibitors); - Hereditary/idiopathic angioedema; - Pregnancy and lactation; - Concomitant use with aliskiren and medicinal products containing aliskiren in patients with diabetes mellitus and/or moderate or severe renal impairment (glomerular filtration rate (GFR) <60 mL/min/1.73m2 body surface area); - Concomitant use with angiotensin II receptor antagonists (ARBs) in patients with diabetic nephropathy; - Concomitant use with combined medicinal products containing valsartan + sacubitril; - Extracorporeal therapy leading to blood contact with negatively charged surfaces; - Severe bilateral renal artery stenosis or stenosis of the artery of a single functioning kidney.