Use Tiregis-D is used to lower high blood pressure (in essential hypertension) in adult patients when telmisartan monotherapy is not effective enough. Each Tiregis-D tablet contains two active ingredients - telmisartan and hydrochlorothiazide, which help control high blood pressure. Telmisartan belongs to angiotensin II receptor antagonists, blocking the narrowing of blood vessels and lowering blood pressure. Hydrochlorothiazide is a thiazide diuretic with a diuretic effect, which also contributes to lowering blood pressure. How to take Tiregis-D tablets should be taken orally once a day, in the morning, regardless of food intake. Tablets can be taken with or without food. Contraindications Do not take Tiregis-D in the following cases: - If you are allergic to telmisartan, hydrochlorothiazide, or any other sulfonamide derivatives, or to any of the excipients of the drug. - If you are pregnant for more than 3 months (it is recommended to stop taking Tiregis-D at earlier stages of pregnancy as well). - In severe liver damage, such as cholestasis or obstruction of the bile ducts (impaired bile flow from the liver or gallbladder), or other serious liver diseases. - In severe kidney diseases. - If your doctor has determined that you have low potassium or high calcium levels in your blood, and these abnormalities persist at the start of Tiregis-D treatment. - In diabetes mellitus or impaired kidney function, if you are also prescribed a medicine containing aliskiren. - Tiregis-D is not recommended for children and adolescents under 18 years of age. Storage Store at a temperature from 2degreeC to 30degreeC.