Nifedi-Denk 20 Retard are prolonged-release tablets containing 20 mg of the active substance - nifedipine. The manufacturer is Denk Pharma, Germany. Nifedipine belongs to the class of calcium channel blockers and has antianginal, antihypertensive, arteriodilating, coronary dilating, hypotensive, and vasodilating effects. Use The drug is used for angina pectoris and essential hypertension (high blood pressure). It can also be used for Raynaud's disease, hypertensive emergency, myocardial infarction, and Prinzmetal's angina. - How to take The dosage regimen is set individually by the attending physician depending on the severity of the disease and the patient's response to the therapy. Tablets should be taken orally, swallowed whole, without chewing or crushing, with or after food, with sufficient water. It is not recommended to take the drug with grapefruit juice, as this can significantly enhance its effect. Doses of the drug should be selected gradually. For essential hypertension, 1 prolonged-release tablet (20 mg) is usually prescribed twice a day. If necessary, the dose can be gradually increased to 2x40 mg of nifedipine.