Use Treatment of arterial hypertension in adults (18 years and older). How to take Orally, regardless of food, with water. Initial dose: 0.2 mg once daily. Maximum single dose: 0.4 mg. Maximum daily dose: 0.6 mg (two administrations). Dose adjusted individually. For renal impairment: start with 0.2 mg/day. Increase to 0.4 mg (moderate severity) or 0.3 mg (severe). For hemodialysis, start with 0.2 mg/day, maximum 0.4 mg. Discontinuation should be gradual (2 weeks). Contraindications - Hypersensitivity to moxonidine. - History of angioedema. - Bradycardia (less than 50 bpm). - Sick sinus syndrome. - II/III degree block (sinoatrial, atrioventricular). - Heart failure (NYHA class III/IV). - Lactation. - Age under 18. - Severe hepatic/chronic renal failure (creatinine clearance less than 30 ml/min). - Concomitant use with tricyclic antidepressants. - Galactose intolerance, lactase deficiency, glucose-galactose malabsorption. Storage Up to 25degreeC, out of reach of children, in a light-protected place.