Captopril-Denk tablets 25mg №100

Use - Treatment of hypertension. - Treatment of chronic heart failure with reduced left ventricular systolic function in combination with diuretics and, if necessary, digitalis and beta-blockers. How to take Captopril can be used as monotherapy or in combination with other antihypertensive agents, especially thiazide diuretics. When used concomitantly with other antihypertensive agents, such as thiazide diuretics, a single daily dose may be prescribed. In patients with hyperactive renin-angiotensin-aldosterone system (hypovolemia, renovascular hypertension, heart failure), the initial dose should be 6.25 mg or 12.5 mg. Treatment should be initiated under close medical supervision, after which the dose can be increased to 50 mg per day, and if necessary, up to 100 mg. The method of administration and dosage regimen of a specific drug depend on its dosage form and other factors. The optimal dosing regimen is determined by the physician. - When taken orally, the initial dose is 6.25-12.5 mg 2-3 times/day. - If the effect is insufficient, the dose is gradually increased to 25-50 mg 3 times/day. - In case of impaired renal function, the daily dose should be reduced. - The maximum daily dose is 150 mg. Contraindications - Hypersensitivity to the active substance, any other ACE inhibitor, or excipients. - History of angioedema associated with previous ACE inhibitor therapy. - Hereditary or idiopathic angioedema. - Concomitant use of captopril with aliskiren-containing medicinal products in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m^2). - Concomitant use with sacubitril/valsartan therapy. Captopril should not be administered within 36 hours after the last dose of sacubitril/valsartan. - Pregnancy and breastfeeding.