Use Lorista is used for the treatment of arterial hypertension. It is also indicated for reducing the risk of cardiovascular diseases and mortality in patients with arterial hypertension and left ventricular hypertrophy. Additionally, Lorista is used to protect the kidneys in patients with type 2 diabetes mellitus with proteinuria. How to take The usual initial and maintenance dose for most patients is 50 mg once daily. The maximum antihypertensive effect is achieved 3-6 weeks after the start of treatment. Subsequently, the dose may be increased to 100 mg/day. For kidney protection in patients with type 2 diabetes mellitus with proteinuria, the standard initial dose of Lorista is 50 mg/day, which may be increased to 100 mg/day taking into account blood pressure reduction. Contraindications - Hypersensitivity to losartan or other components of the drug. - Pregnancy and lactation. - Severe liver dysfunction. - Age under 18 years (efficacy and safety have not been established). - Concomitant use with aliskiren-containing drugs in patients with diabetes mellitus and/or moderate to severe renal impairment (glomerular filtration rate less than 60 ml/min/1.73 m^2 body surface area). - Concomitant use with ACE inhibitors in patients with diabetic nephropathy. Storage Information on storage conditions was not requested in the original prompt, but typically drugs are stored in a dry, dark place, at a temperature not exceeding 25degreeC, out of reach of children.