Use Triplixam is used for the treatment of arterial hypertension in adult patients when blood pressure (BP) is reduced with amlodipine, indapamide, and perindopril at the same doses. How to take The drug is taken orally, 1 tablet once a day, preferably in the morning before meals. The dose of Triplixam is selected after prior titration of the doses of individual components. The maximum daily dose is 1 tablet in a dosage of 10 mg + 2.5 mg + 10 mg. Contraindications - Hypersensitivity to the active and excipient substances included in the drug, sulfonamide derivatives, dihydropyridine derivatives, other ACE inhibitors, or any other substances included in the drug. - Patients undergoing hemodialysis. - Untreated decompensated heart failure. - Severe renal insufficiency (creatinine clearance (CrCl) less than 30 ml/min). - Moderate renal insufficiency (CrCl less than 60 ml/min) for the perindopril/indapamide 10 mg/2.5 mg combination dosage (i.e., Triplixam 5 mg + 2.5 mg + 10 mg and Triplixam 10 mg + 2.5 mg + 10 mg). - Angioedema (Quincke's edema) in history due to ACE inhibitor use. - Hereditary/idiopathic angioedema. - Pregnancy. - Breastfeeding period. - Age under 18 years (efficacy and safety not established).