Use: The drug is indicated for the treatment of essential hypertension. How to take: Take 1 tablet (5 mg/12.5 mg) orally once daily, preferably at the same time. At the start of therapy, the dose of the nebivolol+hydrochlorothiazide combination is 5 mg/12.5 mg/day. If the therapeutic effect is insufficient after 2 weeks, the dose can be increased to 10 mg/25 mg/day. The maximum dose is 10 mg/25 mg/day. Contraindications: - Sick sinus syndrome, including sinoatrial block. - Atrioventricular block II and III degree (without an implanted pacemaker). - Bradycardia (heart rate less than 60 beats/min before treatment). - Arterial hypotension (systolic blood pressure less than 90 mmHg). - Severe peripheral circulatory disorders. - Bronchospasm and bronchial asthma in history. - Untreated pheochromocytoma. - Metabolic acidosis. - Resistant hypokalemia, hypercalcemia, hyponatremia and symptomatic hyperuricemia. - Severe renal failure. - Hepatic insufficiency or impaired liver function.