Use Amprilan ND is indicated for arterial hypertension (in patients requiring combined hypotensive therapy). How to take The dosage regimen for Amprilan ND is established individually. Contraindications Contraindications for the use of Amprilan ND are: - Hypersensitivity to ramipril, other ACE inhibitors, hydrochlorothiazide, other thiazide diuretics, sulfonamides, or to any of the excipients of the drug. - Angioedema in history (hereditary, idiopathic, or associated with previous therapy with ACE inhibitors or angiotensin II receptor antagonists). - Severe renal impairment (creatinine clearance less than 30 ml/min). - Anuria. - Severe hepatic impairment. - Pregnancy. - Breastfeeding period. - Children and adolescents under 18 years of age (efficacy and safety have not been established). - Concomitant use with aliskiren and aliskiren-containing drugs in patients with diabetes mellitus or renal impairment (creatinine clearance less than 60 ml/min). - Concomitant use with angiotensin II receptor antagonists in patients with diabetic nephropathy. - Refractory hypokalemia, hyponatremia, hypercalcemia. - Symptomatic hyperuricemia (gout). - Hereditary lactose intolerance, lactase deficiency, or glucose-galactose malabsorption (the drug contains lactose).