Use Triplixam is used to treat adult patients with arterial hypertension when blood pressure (BP) is lowered by taking amlodipine, indapamide, and perindopril at the same doses. How to take The drug should be taken once a day, in the morning, before meals. It is important to take the drug every day, as regularity of intake makes the treatment more effective. If you forget to take your regular dose of Triplixam, take the next dose at the usual time. Do not take a double dose of the drug to compensate for a missed dose. Do not stop taking Triplixam without prior discussion with your doctor, as treatment for high blood pressure is usually continuous. Contraindications - Hypersensitivity to the active and excipient substances included in the preparation, as well as to sulfonamide derivatives. - Age under 18 years, as the effectiveness and safety of use in this category of patients has not been established. - Severe renal impairment (creatinine clearance (CrCl) less than 30 ml/min). - In patients with moderate renal impairment (CrCl 30-60 ml/min), the use of Triplixam in dosages containing 10 mg of perindopril and 2.5 mg of indapamide (i.e., Triplixam dosages of 5 mg + 2.5 mg + 10 mg and 10 mg + 2.5 mg + 10 mg) is contraindicated. - Concomitant use with aliskiren is contraindicated in patients with diabetes mellitus or renal impairment (glomerular filtration rate (GFR) <60 ml/min/1.73 m2). - Concomitant use of perindopril and potassium-sparing drugs, potassium supplements, or potassium-containing salt substitutes is not recommended.