Use Co-Amlesa is indicated for the treatment of high blood pressure (hypertension) in patients requiring treatment with perindopril, indapamide, and amlodipine in doses available in a fixed combination. All three active substances included in the preparation help control high blood pressure. Patients who are already taking perindopril/indapamide and amlodipine as separate tablets can instead take one tablet of Co-Amlesa, which contains all three components. How to take It is recommended to take 1 tablet of Co-Amlesa once a day, preferably in the morning before meals. Contraindications Do not take Co-Amlesa if you have: - Allergy to perindopril or any other ACE inhibitor, to indapamide or any other sulfonamides, amlodipine besylate or any other dihydropyridines, or to any other components of Co-Amlesa. - Experienced symptoms such as wheezing, swelling of the face or tongue. - Observed intense itching or severe skin rash during previous treatment with an ACE inhibitor, or if you or a family member have shown these symptoms under other circumstances (angioedema). - Severe liver disease or hepatic encephalopathy (degenerative brain disease). - Severe renal insufficiency (creatinine clearance less than 30 ml/min). - Severe kidney disease where blood supply to the kidneys is reduced (renal artery stenosis). - Pregnancy or breastfeeding period. - Low or high blood potassium levels. - Co-Amlesa tablets 8 mg/5 mg/2.5 mg and 8 mg/10 mg/2.5 mg are contraindicated for use in severe and moderate kidney diseases if you are undergoing dialysis or another method of blood filtration. Storage Store at a temperature not exceeding 25 degreeC or not exceeding 30 degreeC in the original packaging to protect from light and moisture. Keep out of reach of children.